Format

Send to

Choose Destination
Trends Biochem Sci. 1990 May;15(5):186-90.

The where, what and how of ribosomal frameshifting in retroviral protein synthesis.

Author information

1
Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

Abstract

The gag and pol genes of most retroviruses occur in different reading frames and their translation as a single polypeptide is carried out by ribosomal frameshifting in the -1 direction. The alignment of the different reading frames occurs by overlapping reading in response to at least two signals within the RNA: one is a heptanucleotide stretch at the frameshift site and the other is a stem-loop structure which occurs just downstream of the first signal.

PMID:
2193436
DOI:
10.1016/0968-0004(90)90159-9
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center