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Eur Heart J. 2012 Feb;33(4):436-43. doi: 10.1093/eurheartj/ehr362. Epub 2011 Sep 19.

Fish oil and omega-3 fatty acids in cardiovascular disease: do they really work?

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Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.


Omega-3 fatty acids, which are found abundantly in fish oil, exert pleiotropic cardiometabolic effects with a diverse range of actions. The results of previous studies raised a lot of interest in the role of fish oil and omega-3 fatty acids in primary and secondary prevention of cardiovascular diseases. The present review will focus on the current clinical uses of omega-3 fatty acids and provide an update on their effects. Since recently published trials in patients with coronary artery diseases or post-myocardial infarction did not show an effect of omega-3 fatty acids on major cardiovascular endpoints, this review will examine the limitations of those data and suggest recommendations for the use of omega-3 fatty acids.

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