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Influenza Other Respir Viruses. 2012 May;6(3):167-75. doi: 10.1111/j.1750-2659.2011.00288.x. Epub 2011 Sep 21.

The potential economic value of a 'universal' (multi-year) influenza vaccine.

Author information

1
Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA. byl1@pitt.edu

Abstract

BACKGROUND:

Limitations of the current annual influenza vaccine have led to ongoing efforts to develop a 'universal' influenza vaccine, i.e., one that targets a ubiquitous portion of the influenza virus so that the coverage of a single vaccination can persist for multiple years.

OBJECTIVES:

To estimate the economic value of a 'universal' influenza vaccine compared to the standard annual influenza vaccine, starting vaccination in the pediatric population (2-18 year olds), over the course of their lifetime.

PATIENT/METHODS:

Monte Carlo decision analytic computer simulation model.

RESULTS:

Universal vaccine dominates (i.e., less costly and more effective) the annual vaccine when the universal vaccine cost ≤ $100/dose and efficacy ≥ 75% for both the 5- and 10-year duration. The universal vaccine is also dominant when efficacy is ≥ 50% and protects for 10 years. A $200 universal vaccine was only cost-effective when ≥ 75% efficacious for a 5-year duration when annual compliance was 25% and for a 10-year duration for all annual compliance rates. A universal vaccine is not cost-effective when it cost $200 and when its efficacy is ≤ 50%. The cost-effectiveness of the universal vaccine increases with the duration of protection.

CONCLUSIONS:

Although development of a universal vaccine requires surmounting scientific hurdles, our results delineate the circumstances under which such a vaccine would be a cost-effective alternative to the annual influenza vaccine.

PMID:
21933357
PMCID:
PMC3253949
DOI:
10.1111/j.1750-2659.2011.00288.x
[Indexed for MEDLINE]
Free PMC Article
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