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Antimicrob Agents Chemother. 2011 Dec;55(12):5952-4. doi: 10.1128/AAC.05108-11. Epub 2011 Sep 19.

A novel variant, NDM-5, of the New Delhi metallo-β-lactamase in a multidrug-resistant Escherichia coli ST648 isolate recovered from a patient in the United Kingdom.

Author information

1
Antimicrobial Research Group, Centre for Immunology and Infectious Disease, Blizard Institute, Barts & The London School ofMedicine and Dentistry, Queen Mary University London, London, United Kingdom.

Abstract

A new variant of the New Delhi metallo-enzyme (NDM) carbapenemase was identified in a multidrug-resistant Escherichia coli ST648 isolate recovered from the perineum and throat of a patient in the United Kingdom with a recent history of hospitalization in India. NDM-5 differed from existing enzymes due to substitutions at positions 88 (Val → Leu) and 154 (Met → Leu) and reduced the susceptibility of E. coli TOP10 transformants to expanded-spectrum cephalosporins and carbapenems when expressed under its native promoter.

PMID:
21930874
PMCID:
PMC3232805
DOI:
10.1128/AAC.05108-11
[Indexed for MEDLINE]
Free PMC Article

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