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Philos Trans R Soc Lond B Biol Sci. 2011 Oct 27;366(1580):2979-86. doi: 10.1098/rstb.2011.0138.

Evolutionary optimization of speed and accuracy of decoding on the ribosome.

Author information

1
Department of Physical Biochemistry, Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, Germany.

Abstract

Speed and accuracy of protein synthesis are fundamental parameters for the fitness of living cells, the quality control of translation, and the evolution of ribosomes. The ribosome developed complex mechanisms that allow for a uniform recognition and selection of any cognate aminoacyl-tRNA (aa-tRNA) and discrimination against any near-cognate aa-tRNA, regardless of the nature or position of the mismatch. This review describes the principles of the selection-kinetic partitioning and induced fit-and discusses the relationship between speed and accuracy of decoding, with a focus on bacterial translation. The translational machinery apparently has evolved towards high speed of translation at the cost of fidelity.

PMID:
21930591
PMCID:
PMC3158919
DOI:
10.1098/rstb.2011.0138
[Indexed for MEDLINE]
Free PMC Article

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