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Philos Trans R Soc Lond B Biol Sci. 2011 Oct 27;366(1580):2902-9. doi: 10.1098/rstb.2011.0139.

The meaning of a minuscule ribozyme.

Author information

1
Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309-0347, USA. yarus@colorado.edu

Abstract

The smallest ribozyme that carries out a complex group transfer is the sequence GUGGC-3', acting to aminoacylate GCCU-3' (and host a manifold of further reactions) in the presence of substrate PheAMP. Here, I describe the enzymatic rate, the characterization of about 20 aminoacyl-RNA and peptidyl-RNA products and the pathways of these GUGGC/GCCU reactions. Finally, the topic is evolution, and the potential implications of these data for the advent of translation itself.

PMID:
21930581
PMCID:
PMC3158920
DOI:
10.1098/rstb.2011.0139
[Indexed for MEDLINE]
Free PMC Article
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