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World J Surg Oncol. 2011 Sep 19;9:107. doi: 10.1186/1477-7819-9-107.

The association of fish consumption with bladder cancer risk: a meta-analysis.

Author information

1
Department of Urology, Affiliated Hospital of School of Medicine of Ningbo University, Ningbo, Zhejiang, 315020, China. mymqq@yahoo.com.cn

Abstract

BACKGROUND:

The association between fish consumption and risk of bladder cancer has not been established yet. The results from epidemiological studies are inconsistent.

METHODS:

We conducted a meta-analysis of cohort and case-control studies on the relationship between fish intake and bladder cancer. We quantified associations with bladder cancer using meta-analysis of relative risk associated to the highest versus the lowest category of fish intake using random effect models. Heterogeneity among studies was examined using Q and I2 statistics. Publication bias was assessed using the Begg's funnel plot.

RESULTS:

Five cohort and 9 case-control studies were eligible for inclusion. The combined relative risk showed that fish consumption was negatively, but not significantly, associated with a decreased risk of bladder cancer (relative risk, 0.86; 95% confidence interval, 0.61-1.12). In subgroup analyses, there was no evidence that study design, geographical region, case sample size, or exposure assessment substantially influenced the estimate of effects.

CONCLUSION:

The overall current literature on fish consumption and the risk of bladder cancer suggested no association. Because of the limited number of studies, further well-designed prospective studies are needed to explore the effect of fish on bladder cancer.

PMID:
21929755
PMCID:
PMC3182909
DOI:
10.1186/1477-7819-9-107
[Indexed for MEDLINE]
Free PMC Article

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