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Nat Chem Biol. 2011 Sep 18;7(12):888-90. doi: 10.1038/nchembio.688.

A natural prodrug activation mechanism in nonribosomal peptide synthesis.

Author information

1
Molecular Biotechnology, Institute for Molecular Biosciences, Goethe University Frankfurt, Frankfurt, Germany.

Abstract

We have identified a new mechanism for the cleavage and activation of nonribosomally made peptides and peptide-polyketide hybrids that are apparently operational in several different bacteria. This process includes the cleavage of a precursor molecule by a membrane-bound and D-asparagine-specific peptidase, as shown here in the biosynthesis of the antibiotic xenocoumacin from Xenorhabdus nematophila.

PMID:
21926994
DOI:
10.1038/nchembio.688
[Indexed for MEDLINE]

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