Format

Send to

Choose Destination
Nat Neurosci. 2011 Sep 18;14(10):1338-44. doi: 10.1038/nn.2921.

Medial prefrontal cortex as an action-outcome predictor.

Author information

1
Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, USA.

Abstract

The medial prefrontal cortex (mPFC) and especially anterior cingulate cortex is central to higher cognitive function and many clinical disorders, yet its basic function remains in dispute. Various competing theories of mPFC have treated effects of errors, conflict, error likelihood, volatility and reward, using findings from neuroimaging and neurophysiology in humans and monkeys. No single theory has been able to reconcile and account for the variety of findings. Here we show that a simple model based on standard learning rules can simulate and unify an unprecedented range of known effects in mPFC. The model reinterprets many known effects and suggests a new view of mPFC, as a region concerned with learning and predicting the likely outcomes of actions, whether good or bad. Cognitive control at the neural level is then seen as a result of evaluating the probable and actual outcomes of one's actions.

PMID:
21926982
PMCID:
PMC3183374
DOI:
10.1038/nn.2921
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center