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Cornea. 2011 Nov;30(11):1264-6. doi: 10.1097/ICO.0b013e31821d876d.

Microsporidial stromal keratitis successfully treated with medical therapy: a case report.

Author information

1
Cornea and Anterior Segment Services, L.V. Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, India.

Abstract

PURPOSE:

To report a case of stromal microsporidiosis that responded to medical treatment with systemic albendazole and topical chlorhexidine.

METHODS:

A 14-year-old adolescent girl presented with a 3-month history of recurrent redness, pain, and dense anterior stromal corneal infiltrate. Repeated microbiological evaluation helped identify microsporidia from the fifth scraping. Initial therapy with fluoroquinolones failed; 0.02% topical chlorhexidine gluconate hourly and 400 mg of oral albendazole twice daily and later 0.5% loteprednol etabonate were given for a total of 12 weeks.

RESULTS:

There was complete resolution of the infection with corneal scarring with no episodes of recurrence at 1 year of follow-up. The final best-corrected visual acuity was 20/30.

CONCLUSIONS:

The diagnosis of microsporidia can be challenging, and corneal scraping should be repeated several times in cases having a high index of suspicion. Medical therapy can prove successful in selected cases where the infection may be limited to midstroma.

PMID:
21926563
DOI:
10.1097/ICO.0b013e31821d876d
[Indexed for MEDLINE]

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