Preparation of magnetically separable N-halamine nanocomposites for the improved antibacterial application

J Colloid Interface Sci. 2011 Dec 15;364(2):333-40. doi: 10.1016/j.jcis.2011.08.036. Epub 2011 Aug 23.

Abstract

Magnetic N-halamine nanocomposites were synthesized through the encapsulation of the magnetic silica nanoparticles with antibacterial N-halamine polymer. The as-synthesized sample was characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS), Fourier transform infrared (FTIR), X-ray diffraction (XRD), X-ray photoelectron spectra (XPS), and thermogravimetric analysis (TGA). The fabricated magnetic N-halamine nanocomposites possessed enhanced antibacterial activity against both gram-positive and gram-negative bacteria compared with their bulk counterparts. The effect of chlorine content of the magnetic N-halamine nanocomposites on the antibacterial activity was investigated. The magnetic N-halamine nanocomposites also exhibited super-paramagnetic behavior and had a saturation magnetization of 4.728 emu g(-1) at room temperature, which made these nanocomposites separable magnetically after the antibacterial behavior. Performances derived from the synergism between magnetic core and antibacterial shell suggest that the magnetic N-halamine nanocomposites are qualified for antibacterial applications and separable by the aid of the external magnetic field.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / chemistry*
  • Amines / isolation & purification
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Magnetics*
  • Microbial Sensitivity Tests
  • Microscopy, Electron, Transmission
  • Nanocomposites*
  • Spectroscopy, Fourier Transform Infrared
  • X-Ray Diffraction

Substances

  • Amines
  • Anti-Bacterial Agents