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Adv Drug Deliv Rev. 2012 Feb;64(2):200-16. doi: 10.1016/j.addr.2011.08.006. Epub 2011 Sep 6.

Monolayer coated gold nanoparticles for delivery applications.

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1
Department of Chemistry, University of Massachusetts at Amherst, Amherst, MA-01003, USA.

Abstract

Gold nanoparticles (AuNPs) provide attractive vehicles for delivery of drugs, genetic materials, proteins, and small molecules. AuNPs feature low core toxicity coupled with the ability to parametrically control particle size and surface properties. In this review, we focus on engineering of the AuNP surface monolayer, highlighting recent advances in tuning monolayer structures for efficient delivery of drugs and biomolecules. This review covers two broad categories of particle functionalization, organic monolayers and biomolecule coatings, and discusses their applications in drug, DNA/RNA, protein and small molecule delivery.

PMID:
21925556
PMCID:
PMC3258479
DOI:
10.1016/j.addr.2011.08.006
[Indexed for MEDLINE]
Free PMC Article
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