Format

Send to

Choose Destination
See comment in PubMed Commons below
Mol Cell. 2011 Sep 16;43(6):867-79. doi: 10.1016/j.molcel.2011.08.024.

Prospects for riboswitch discovery and analysis.

Author information

1
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520-8103, USA. ronald.breaker@yale.edu

Abstract

An expanding number of metabolite-binding riboswitch classes are being discovered in the noncoding portions of bacterial genomes. Findings over the last decade indicate that bacteria commonly use these RNA genetic elements as regulators of metabolic pathways and as mediators of changes in cell physiology. Some riboswitches are surprisingly complex, and they rival protein factors in their structural and functional sophistication. Each new riboswitch discovery expands our knowledge of the biochemical capabilities of RNA, and some give rise to new questions that require additional study to be addressed. Some of the greatest prospects for riboswitch research and some of the more interesting mysteries are discussed in this review.

PMID:
21925376
PMCID:
PMC4140403
DOI:
10.1016/j.molcel.2011.08.024
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center