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Cell. 2011 Sep 16;146(6):873-87. doi: 10.1016/j.cell.2011.08.039.

Basic and therapeutic aspects of angiogenesis.

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1
Vascular Epigenetics Group, Institute for Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University, D-60590 Frankfurt, Germany.

Abstract

Blood vessels form extensive networks that nurture all tissues in the body. Abnormal vessel growth and function are hallmarks of cancer and ischemic and inflammatory diseases, and they contribute to disease progression. Therapeutic approaches to block vascular supply have reached the clinic, but limited efficacy and resistance pose unresolved challenges. Recent insights establish how endothelial cells communicate with each other and with their environment to form a branched vascular network. The emerging principles of vascular growth provide exciting new perspectives, the translation of which might overcome the current limitations of pro- and antiangiogenic medicine.

PMID:
21925313
DOI:
10.1016/j.cell.2011.08.039
[Indexed for MEDLINE]
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