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Neuroimage. 2012 Jan 16;59(2):1904-11. doi: 10.1016/j.neuroimage.2011.08.098. Epub 2011 Sep 8.

Gamma band pitch responses in human auditory cortex measured with magnetoencephalography.

Author information

1
Auditory Group, Institute of Neuroscience, Newcastle University Medical School, Newcastle Upon Tyne, Tyne and Wear, NE2 4HH UK. willsedley@gmail.com

Abstract

We have previously used direct electrode recordings in two human subjects to identify neural correlates of the perception of pitch (Griffiths, Kumar, Sedley et al., Direct recordings of pitch responses from human auditory cortex, Curr. Biol. 22 (2010), pp. 1128-1132). The present study was carried out to assess virtual-electrode measures of pitch perception based on non-invasive magnetoencephalography (MEG). We recorded pitch responses in 13 healthy volunteers using a passive listening paradigm and the same pitch-evoking stimuli (regular interval noise; RIN) as in the previous study. Source activity was reconstructed using a beamformer approach, which was used to place virtual electrodes in auditory cortex. Time-frequency decomposition of these data revealed oscillatory responses to pitch in the gamma frequency band to occur, in Heschl's gyrus, from 60 Hz upwards. Direct comparison of these pitch responses to the previous depth electrode recordings shows a striking congruence in terms of spectrotemporal profile and anatomical distribution. These findings provide further support that auditory high gamma oscillations occur in association with RIN pitch stimuli, and validate the use of MEG to assess neural correlates of normal and abnormal pitch perception.

PMID:
21925281
PMCID:
PMC3236996
DOI:
10.1016/j.neuroimage.2011.08.098
[Indexed for MEDLINE]
Free PMC Article

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