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Cell Host Microbe. 2011 Sep 15;10(3):177-8. doi: 10.1016/j.chom.2011.08.011.

HCMV grabs a mechanism to escape neutralization.

Author information

1
School of Veterinary Medicine, University of Pennsylvania, Philadelphia, USA. roselyn@dental.upenn.edu

Abstract

The HCMV-neutralizing monoclonal antibody MSL-109 failed to prevent HCMV-induced disease in the clinic. In this issue of Cell Host & Microbe, Manley et al. (2011) found that MSL-109 rapidly induces antibody resistance by a nongenetic mechanism. Their results shed light on how antibodies can interact with their targets both outside and inside infected cells and virions.

PMID:
21925104
DOI:
10.1016/j.chom.2011.08.011
[Indexed for MEDLINE]
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