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Semin Cell Dev Biol. 2012 Apr;23(2):145-53. doi: 10.1016/j.semcdb.2011.09.002. Epub 2011 Sep 8.

Ras trafficking, localization and compartmentalized signalling.

Author information

1
Physiological Laboratory, Department of Molecular and Cellular Physiology, Institute of Translational Research, University of Liverpool, Crown St., Liverpool L69 3BX, UK. iprior@liverpool.ac.uk

Abstract

Ras proteins are proto-oncogenes that are frequently mutated in human cancers. Three closely related isoforms, HRAS, KRAS and NRAS, are expressed in all cells and have overlapping but distinctive functions. Recent work has revealed how differences between the Ras isoforms in their trafficking, localization and protein-membrane orientation enable signalling specificity to be determined. We review the various strategies used to characterize compartmentalized Ras localization and signalling. Localization is an important contextual modifier of signalling networks and insights from the Ras system are of widespread relevance for researchers interested in signalling initiated from membranes.

PMID:
21924373
PMCID:
PMC3378476
DOI:
10.1016/j.semcdb.2011.09.002
[Indexed for MEDLINE]
Free PMC Article

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