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Methods Cell Biol. 2011;104:51-8. doi: 10.1016/B978-0-12-374814-0.00003-3.

Engineering zinc finger nucleases for targeted mutagenesis of zebrafish.

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Molecular Pathology Unit, Center for Computational and Integrative Biology, and Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, USA.


Zinc finger nucleases provide an important platform for performing reverse genetics in zebrafish. Here we review various methods and resources that have been used to create customized zinc finger nucleases for use in zebrafish. We also provide a framework for choosing among the various publicly available platforms available to engineer ZFNs.

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