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J Eur Acad Dermatol Venereol. 2011 Oct;25(10):1225-9. doi: 10.1111/j.1468-3083.2010.03922.x. Epub 2010 Nov 25.

Lacking CD56 expression in a relapsing cutaneous blastic plasmacytoid dendritic cell neoplasm after allogeneic bone marrow transplantation: FISH analysis revealed loss of 11q.

Author information

1
Department of Dermatology, Georg August University Göttingen, Germany. christina.mitteldorf@klinikum-hildesheim.de

Abstract

BACKGROUND:

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare entity characterized by a CD4+/CD56+/CD123+ immunophenotype and a fatal clinical course. The average survival of 12-14 months may be prolonged by allogeneic bone marrow transplantation (BMT).

OBJECTIVES:

We report about a male patient who suffered from BPDCN with a typical histology and co-expression of CD4/CD123 and a CD56 expression by 80% of the tumour cells. The cutaneous tumour relapse after chemotherapy and allogeneic BMT was completely negative for CD56.

METHODS:

We performed interphase fluorescence in situ hybridization (FISH) analysis of tumour tissue, asserved before and after BMT, using specific probes for chromosome 11, which encompass the CD56 gene region.

RESULTS:

The tumour cells revealed a partial loss of 11q as well as a monosomy of chromosome 11.

CONCLUSION:

This case demonstrates for the first time that loss of CD56 expression can also occur as a secondary event after chemotherapy and BMT. In our case, DNA loss of 11q23 could be responsible for the negativity of 20% of tumour cells as observed before chemotherapy. However, the complete loss of CD56 expression in the relapsed tumour cannot be explained by the loss of 11q23 alone. Additional factors such as chemotherapy-induced mutations might also have contributed.

[Indexed for MEDLINE]

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