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J Med Chem. 2011 Oct 27;54(20):7127-37. doi: 10.1021/jm200716y. Epub 2011 Sep 29.

Synthesis and study of a series of 3-arylcoumarins as potent and selective monoamine oxidase B inhibitors.

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1
Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain. mariajoao.correiapinto@rai.usc.es

Abstract

New series of 6-substituted-3-arylcoumarins displaying several alkyl, hydroxyl, halogen, and alkoxy groups in the two benzene rings have been designed, synthesized, and evaluated in vitro as human monoamine oxidase A and B (hMAO-A and hMAO-B) inhibitors. Most of the studied compounds showed a high affinity and selectivity to the hMAO-B isoenzyme, with IC(50) values on nanomolar and picomolar range. Ten of the 22 described compounds displayed higher MAO-B inhibitory activity and selectivity than selegiline. Coumarin 7 is the most active compound of this series, being 64 times more active than selegiline and also showing the highest hMAO-B specificity. In addition, docking experiments were carried out on hMAO-A and h-MAO-B structures. This study provided new information about the enzyme-inhibitor interaction and the potential therapeutic application of this 3-arylcoumarin scaffold.

PMID:
21923181
DOI:
10.1021/jm200716y
[Indexed for MEDLINE]

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