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Trop Gastroenterol. 2011 Jan-Mar;32(1):50-5.

Serum IL-6 and IL-8 in infants with biliary atresia in comparison to intrahepatic cholestasis.

Author information

1
Department of Paeditrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt. amelhome4@gmail.com

Abstract

BACKGROUND:

Biliary atresia (BA) is an idiopathic progressive inflammation and fibrosclerosis of the extra and intrahepatic bile ducts.

AIM:

To measure the serum levels of IL-6 and IL-8 in biliary atresia and correlate with clinical outcome.

METHODS:

Sixty children were included, 20 with BA (group 1), 20 with intrahepatic cholestasis (group 2) and 20 normal children as controls. Complete blood count (CBC), liver function tests, serum IL-6 and IL-8 were analyzed in all the three groups.

RESULTS:

Mean serum IL-6 and IL-8 levels were significantly higher in group 1 (394.7 +/- 40.2 and 111.2 +/- 9.7 pg/dl, respectively) than group 2 (175.5 +/- 33.1 and 53.5 +/- 8.2 pg/dl, respectively) (p=0.0 for both). Both IL-6 and IL-8 were significantly higher in both the disease groups compared to controls (30.4 +/- 8.8 and 13.7 +/- 4.1 pg/dl, respectively). IL-8 showed a significant positive correlation with lymphocytes and significant negative correlation with albumin in group 1. Higher IL-6 was found in patients with BA with severe fibrosis than in patients with mild fibrosis while higher IL-8 was found in children with persistent jaundice than those free from jaundice in group 1.

CONCLUSION:

Serum IL-6 and IL8 are high in patients with BA indicating ongoing inflammation. They may serve to determine disease severity and may predict the progression to liver fibrosis in these cases.

PMID:
21922857
[Indexed for MEDLINE]
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