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Nat Rev Genet. 2011 Sep 16;12(10):730-6. doi: 10.1038/nrg3067.

Assessing and managing risk when sharing aggregate genetic variant data.

Author information

1
Translational Genomics Research Institute (TGen), Phoenix, Arizona 85004, USA. dcraig@tgen.org

Erratum in

  • Nat Rev Genet. 2011 Nov;12(11):801.

Abstract

Access to genetic data across studies is an important aspect of identifying new genetic associations through genome-wide association studies (GWASs). Meta-analysis across multiple GWASs with combined cohort sizes of tens of thousands of individuals often uncovers many more genome-wide associated loci than the original individual studies; this emphasizes the importance of tools and mechanisms for data sharing. However, even sharing summary-level data, such as allele frequencies, inherently carries some degree of privacy risk to study participants. Here we discuss mechanisms and resources for sharing data from GWASs, particularly focusing on approaches for assessing and quantifying the privacy risks to participants that result from the sharing of summary-level data.

PMID:
21921928
PMCID:
PMC3349221
DOI:
10.1038/nrg3067
[Indexed for MEDLINE]
Free PMC Article

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