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Obes Facts. 2011;4(4):312-8. doi: 10.1159/000330710. Epub 2011 Aug 1.

Plasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change.

Author information

1
Department of Clinical Epidemiology, School of Public Health, Aarhus University, Aarhus University Hospital, Aalborg, Denmark. muj@soci.au.dk

Abstract

OBJECTIVE:

We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers.

METHOD:

A total of 1,998 women and men participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 4.9 years. The associations between the proportion of plasma phospholipid long-chain n-3 PUFA and change in weight were investigated using mixed-effect linear regression.

RESULTS:

The proportion of long-chain n-3 PUFA was not associated with change in weight. Among all participants, the 1-year weight change was -0.7 g per 1% point higher long-chain n-3 PUFA level (95% confidence interval: -20.7 to 19.3). The results when stratified by sex, age, or BMI groups were not systematically different.

CONCLUSION:

The results of this study suggest that the proportion of long-chain n-3 PUFA in plasma phospholipids is not associated with subsequent change in body weight within the range of exposure in the general population.

PMID:
21921655
DOI:
10.1159/000330710
[Indexed for MEDLINE]
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