Format

Send to

Choose Destination
Biochim Biophys Acta. 2011 Dec;1812(12):1630-9. doi: 10.1016/j.bbadis.2011.08.012. Epub 2011 Sep 2.

Brain aging, Alzheimer's disease, and mitochondria.

Author information

1
Department of Neurology, University of Kansas School of Medicine, Kansas City, KS, USA. rswerdlow@kumc.edu

Abstract

The relationship between brain aging and Alzheimer's disease (AD) is contentious. One view holds AD results when brain aging surpasses a threshold. The other view postulates AD is not a consequence of brain aging. This review discusses this conundrum from the perspective of different investigative lines that have tried to address it, as well as from the perspective of the mitochondrion, an organelle that appears to play a role in both AD and brain aging. Specific issues addressed include the question of whether AD and brain aging should be conceptually lumped or split, the extent to which AD and brain aging potentially share common molecular mechanisms, whether beta amyloid should be primarily considered a marker of AD or simply brain aging, and the definition of AD itself.

PMID:
21920438
PMCID:
PMC3210037
DOI:
10.1016/j.bbadis.2011.08.012
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center