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Dev Cell. 2011 Sep 13;21(3):392-3. doi: 10.1016/j.devcel.2011.08.021.

Heart development: mitochondria in command of cardiomyocyte differentiation.

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1
Max-Delbrück-Center for Molecular Medicine, 13125 Berlin, Germany. drenckhahn@mdc-berlin.de

Abstract

Continuous developmental maturation of cardiomyocytes is essential to meet the functional and metabolic demands of the growing heart. A new study (Hom et al., 2011) reports that embryonic cardiomyocytes are influenced by mitochondrial maturation, such that closure of the mitochondrial permeability transition pore results in decreased levels of reactive oxygen species, thereby inducing differentiation.

PMID:
21920309
DOI:
10.1016/j.devcel.2011.08.021
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