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Dev Cell. 2011 Sep 13;21(3):385-6. doi: 10.1016/j.devcel.2011.08.023.

Between the sheets: a molecular sieve makes myelin membranes.

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Department of Neurobiology, Stanford University School of Medicine, Stanford, California 94305-5125, USA.


Myelin is a lipid-rich, spiraled membrane structure that allows for rapid propagation of action potentials through axons. In this issue, Aggarwal et al. (2011) present evidence that myelin basic protein, essential for myelination by oligodendrocytes, regulates the biosynthesis of myelin membranes by restricting diffusion of membrane-bound proteins into compact myelin.

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