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Kidney Int. 2011 Oct;80(7):692-3. doi: 10.1038/ki.2011.175.

The next level of complexity: post-transcriptional regulation by microRNAs.

Author information

1
Division of Nephrology and Immunology, University Hospital of the Aachen University of Technology (RWTH), Aachen, Germany.

Abstract

MicroRNAs (miRNAs) are endogenous, small, noncoding RNAs that regulate expression of about half of human genes. Canonical miRNA biosynthesis involves two RNase III-type proteins, Drosha and Dicer. A podocyte-specific knockout of Dicer resulted in foot process effacement. In this issue, Zhdanova et al. report on targeting Drosha in a podocyte-specific fashion. Their study demonstrates an essential role of canonical miRNAs in maintaining the fully differentiated podocyte phenotype.

PMID:
21918556
DOI:
10.1038/ki.2011.175
[Indexed for MEDLINE]
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