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Exerc Sport Sci Rev. 2012 Jan;40(1):43-9. doi: 10.1097/JES.0b013e3182355e8c.

Endoplasmic reticulum stress in skeletal muscle: origin and metabolic consequences.

Author information

1
Research Centre for Exercise and Health, Department of Biomedical Kinesiology, K.U. Leuven, Belgium. louise.deldicque@faber.kuleuven.be

Abstract

In secretory organs, such as the liver, the pancreas, and the adipose tissue, endoplasmic reticulum (ER) stress plays a key role in the etiology of cell disturbances implicated in many diseases. Although much less studied, ER stress also is present in skeletal muscle. In the present review, we hypothesize that ER stress may have important metabolic consequences in skeletal muscle. This review presents the situations in which ER stress is activated in skeletal muscle and its metabolic consequences.

PMID:
21918459
DOI:
10.1097/JES.0b013e3182355e8c
[Indexed for MEDLINE]

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