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Pediatr Dermatol. 2011 Sep-Oct;28(5):524-7. doi: 10.1111/j.1525-1470.2011.01305.x.

S100-negative indeterminate cell histiocytosis in an African American child responsive to narrowband ultraviolet B.

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Department of Dermatology and Cutaneous Surgery, University of Miami, Miller School of Medicine, Miami, Florida 33125, USA.


Indeterminate cell histiocytosis is a rare cutaneous disease characterized by the presence of dendritic cells that lack Birbeck granules and immunophenotypically shares features of both Langerhans cells and macrophages. We describe a case of a 4-year-old African American boy affected by a disseminated, exclusively mucocutaneous form of indeterminate cell histiocytosis. The eruption was successfully treated with narrowband ultraviolet B. The peculiar negativity of the Langerhans cell marker S100 is also discussed.

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