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Comput Methods Biomech Biomed Engin. 2013;16(1):95-102. doi: 10.1080/10255842.2011.607445. Epub 2011 Sep 14.

Analytical modelling of retrograde transport of nerve growth factors in an axon: a transient problem.

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1
Department of Mechanical and Aerospace Engineering, North Carolina State University, Campus Box 7910, Raleigh, NC 27695-7910, USA. avkuznet@eos.ncsu.edu

Abstract

The purpose of this paper was to develop an analytical solution describing retrograde transport of nerve growth factors (NGFs) from a target tissue to the neuron soma. The obtained solution is applied to describe two situations: (1) when all dynein motors are moving at a constant velocity and (2) when the dynein velocity distribution is described by a probability density function. The dynamics of NGF concentrations and fluxes is investigated. It is established that the magnitude of the diffusion flux forms a wave localised in space and propagating towards the neuron soma; the magnitude of this wave decreases as the wave propagates downstream. The dynein-driven flux of NGFs is demonstrated to be the main component in the NGF flux, which is shown to be strongly correlated with the NGF concentration.

PMID:
21916675
DOI:
10.1080/10255842.2011.607445
[Indexed for MEDLINE]
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