Format

Send to

Choose Destination
See comment in PubMed Commons below
Adv Exp Med Biol. 2011;722:137-55. doi: 10.1007/978-1-4614-0332-6_9.

Unexpected functions of tRNA and tRNA processing enzymes.

Author information

  • 1Department of Molecular Genetics, The Ohio State University, Columbus, USA. hurto.1@osu.edu

Abstract

tRNA and tRNA processing enzymes impact more than protein production. Studies have uncovered roles for tRNA in the regulation of transcription, translation and protein turnover. Induced by stress or as a programmed part of development, nonrandom tRNA fragments can guide mRNA cleavage, inhibit translation and promote morphological changes. Similarly, tRNA processing enzymes, such as RNaseP and tRNA aminoacyl-synthetases participate in tasks affecting more than tRNA function (i.e., mRNA function and cellular signaling). Unraveling the complexities of their functions will increase our understanding of how mutations associated with disease impact these functions and the downstream consequences. This chapter focuses on how tRNA and tRNA processing enzymes influence cellular function and RNA-infrastructure via pathways beyond the decoding activities that tRNA are known for.

PMID:
21915787
DOI:
10.1007/978-1-4614-0332-6_9
[PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center