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Open Neurol J. 2011;5:58-62. doi: 10.2174/1874205X01105010058. Epub 2011 Aug 26.

Neurofilamentopathy in neurodegenerative diseases.

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School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.


Neurofilament protein alterations are found in many neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson, Alzheimer, and Charcot-Marie-Tooth. Abnormal modifications of neurofilament, such as mutation, oxidation and phosphorylation, are linked to the disease-related alteration. In this review, the most recent discovery and central arguments about functions, pathological modifications, and genetic mutations related to neurofilaments in neurodegenerative diseases is presented.


Alzheimer disease; Amyotrophic lateral sclerosis; Glycosylation.; Neurofilament; Oxidation; Parkinson disease; Phosphorylation

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