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Cornea. 2011 Nov;30(11):1213-8. doi: 10.1097/ICO.0b013e31821c9b44.

A randomized controlled trial of intralesional bevacizumab injection on primary pterygium: preliminary results.

Author information

1
Department of Ophthalmology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Abstract

PURPOSE:

To evaluate the efficacy and safety of intralesional injection of bevacizumab on primary pterygium treatment.

METHODS:

In this randomized controlled trial, each primary pterygium patient was randomized to receive either an intralesional injection of bevacizumab 2 mg (1 mg/0.04 mL) or a combination of topical antihistamine (antazoline HCl 0.05%) and vasoconstrictor (tetrahydrozoline HCl 0.04%) as a control. The main outcome measurements were symptoms and signs (including eye irritation, epiphora, redness, amount of discharge, inflammation and elevation of pterygium, and percentage of corneal pterygium area).

RESULTS:

A total of 74 pterygium eyes in 66 patients were randomized and allocated into a treatment group (N = 34) and a control group (N = 40). In the treatment group, there was a statistically significant reduction of symptoms (including irritation, photophobia, epiphora, redness, discharge, and blurred vision) and signs (inflammation and corneal pterygium area) compared with the baseline, up to at least 6 months. Between the treatment and control groups, no significant differences were found for all visits with respect to the (1) symptoms, (2) signs, and (3) percentage of corneal pterygium.

CONCLUSIONS:

Intralesional bevacizumab may have a therapeutic effect on symptoms and signs of primary pterygium for at least 6 months (ie, the follow-up period), with no serious ocular or systemic adverse effects.

PMID:
21915047
DOI:
10.1097/ICO.0b013e31821c9b44
[Indexed for MEDLINE]

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