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Asian Pac J Trop Med. 2011 Aug;4(8):654-7. doi: 10.1016/S1995-7645(11)60166-1.

Antifungal activity of Ocimum sanctum Linn. (Lamiaceae) on clinically isolated dermatophytic fungi.

Author information

1
Department of Chemistry and Biosciences, SASTRA University, Srinivasa Ramanujan Centre, Kumbakonam, Tamil Nadu, India.

Abstract

OBJECTIVE:

To assess antifungal activity of Ocimum sanctum leaves against dermatophytic fungi.

METHODS:

Antifungal activity of Ocimum sanctum leaves was measured by 38 A NCCLS method. Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of various extracts and fractions of Ocimum sanctum leaves were also determined.

RESULTS:

Ocimum sanctum leaves possessed antifungal activity against clinically isolated dermatophytes at the concentration of 200 μg/mL. MIC and MFC were high with water fraction (200 μg/mL) against dermatophytic fungi used.

CONCLUSIONS:

Ocimum sanctum has antifungal activity, and the leaf extracts may be a useful source for dermatophytic infections.

PMID:
21914546
DOI:
10.1016/S1995-7645(11)60166-1
[Indexed for MEDLINE]
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