Format

Send to

Choose Destination
Asian Pac J Trop Med. 2011 Aug;4(8):642-4. doi: 10.1016/S1995-7645(11)60163-6.

Phytopharmacological evaluation and anti-asthmatic activity of Ficus religiosa leaves.

Author information

1
Department of Phytopharmaceuticals and Natural Products, Institute of Pharmacy, Nirma University, Ahmedabad, India.

Abstract

OBJECTIVE:

To discuss phytopharmacological potential and anti-asthmatic activity of Ficus religiosa (F. religiosa) (L.).

METHODS:

Fresh leaves of F. religiosa were obtained from Vastrapur Lake, Ahmedabad, and dried to obtain powder. Histamine and acetylcholine were used to guinea pigs to establish bronchospasm model. In in vivo study, the aqueous extract of F. religiosa leaves (AEFR) at doses of 150 and 300 mg/kg was administrated to guinea pigs, and the broncho-protective activity of AEFR was compared with aminophylline at 25 mg/kg. While in in vitro study, and 10 g/mL, 20 g/mL, 30 g/mL of AEFRL was administrated to guinea pigs, respectively, and mast cell stabilizing activity of AEFR was compared with ketotifen at 10 g/mL.

RESULTS:

In the in-vivo model, pre-treatment with aminophylline (25 mg/kg, ip.) could significantly delay the onset of histamine induced pre-convulsive dyspnea, compared with vehicle control. Administration of AEFRL (150 and 300 mg/kg, ip.) also produced significant effect on latency to develop histamine & acetylcholine induced pre-convulsive dyspnea. In the mast cell stabilizing model, AEFRL at 10, 20 and 30 μg/mL could significantly increase the number of intact cells.

CONCLUSIONS:

It can be concluded that AEFRL is effective on histamine & acetylcholine induced bronchospasm in guinea pigs. In addition, AEFRL can potentiate the number of intact cells in the mast cell stabilizing model.

PMID:
21914543
DOI:
10.1016/S1995-7645(11)60163-6
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center