Format

Send to

Choose Destination
Public Health Nutr. 2012 Apr;15(4):725-37. doi: 10.1017/S1368980011002254. Epub 2011 Sep 14.

Fish consumption and CHD mortality: an updated meta-analysis of seventeen cohort studies.

Author information

1
Department of Food Science and Nutrition, Zhejiang University, 268 Kaixuan Road, Hangzhou 310029, People's Republic of China.

Abstract

OBJECTIVE:

Results of studies on fish consumption and CHD mortality are inconsistent. The present updated meta-analysis was conducted to investigate the up-to-date pooling effects.

DESIGN:

A random-effects model was used to pool the risk estimates. Generalized least-squares regression and restricted cubic splines were used to assess the possible dose-response relationship. Subgroup analyses were conducted to examine the sources of heterogeneity.

SETTING:

PubMed and ISI Web of Science databases up to September 2010 were searched and secondary referencing qualified for inclusion in the study.

SUBJECTS:

Seventeen cohorts with 315,812 participants and average follow-up period of 15·9 years were identified.

RESULTS:

Compared with the lowest fish intake (<1 serving/month or 1-3 servings/month), the pooled relative risk (RR) of fish intake on CHD mortality was 0·84 (95% CI 0·75, 0·95) for low fish intake (1 serving/week), 0·79 (95% CI 0·67, 0·92) for moderate fish intake (2-4 servings/week) and 0·83 (95% CI 0·68, 1·01) for high fish intake (>5 servings/week). The dose-response analysis indicated that every 15 g/d increment of fish intake decreased the risk of CHD mortality by 6% (RR = 0·94; 95% CI 0·90, 0·98). The method of dietary assessment, gender and energy adjustment affected the results remarkably.

CONCLUSIONS:

Our results indicate that either low (1 serving/week) or moderate fish consumption (2-4 servings/week) has a significantly beneficial effect on the prevention of CHD mortality. High fish consumption (>5 servings/week) possesses only a marginally protective effect on CHD mortality, possibly due to the limited studies included in this group.

PMID:
21914258
DOI:
10.1017/S1368980011002254
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Cambridge University Press
Loading ...
Support Center