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Antimicrob Agents Chemother. 2011 Dec;55(12):5939-41. doi: 10.1128/AAC.00314-11. Epub 2011 Sep 12.

Ribosomal mutations as the main cause of macrolide resistance in Campylobacter jejuni and Campylobacter coli.

Author information

1
Antimicrobial Resistance Unit, National Institute for Health and Welfare, THL, Kiinamyllynkatu 13, 20520 Turku, Finland. mipleht@utu.fi

Abstract

The aim of this study was to examine macrolide resistance mutations in Campylobacter species. In 76 strains studied, point mutation A to G at position 2059 of the 23S rRNA gene was detected in 30 of the 33 erythromycin-resistant strains. An amino acid insertion in the ribosomal protein L22 was found in one resistant strain without a 23S rRNA mutation. The A2059G mutation is the main cause of macrolide resistance in Campylobacter species.

PMID:
21911571
PMCID:
PMC3232809
DOI:
10.1128/AAC.00314-11
[Indexed for MEDLINE]
Free PMC Article

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