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Microbes Infect. 2011 Dec;13(14-15):1185-90. doi: 10.1016/j.micinf.2011.08.006. Epub 2011 Aug 30.

Contribution of the enterococcal surface protein Esp to pathogenesis of Enterococcus faecium endocarditis.

Author information

1
Department of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. e.heikens@umcutrecht.nl

Abstract

The enterococcal surface protein Esp, specifically linked to nosocomial Enterococcus faecium, is involved in biofilm formation. To assess the role of Esp in endocarditis, a biofilm-associated infection, an Esp-expressing E. faecium strain (E1162) or its Esp-deficient mutant (E1162Δesp) were inoculated through a catheter into the left ventricle of rats. After 24 h, less E1162Δesp than E1162 were recovered from heart valve vegetations. In addition, anti-Esp antibodies were detected in Esp-positive E. faecium bacteremia and endocarditis patient sera. In conclusion, Esp contributes to colonization of E. faecium at the heart valves. Furthermore, systemic infection elicits an Esp-specific antibody response in humans.

PMID:
21911077
PMCID:
PMC3221784
DOI:
10.1016/j.micinf.2011.08.006
[Indexed for MEDLINE]
Free PMC Article

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