Format

Send to

Choose Destination
Annu Rev Genet. 2011;45:331-55. doi: 10.1146/annurev-genet-110410-132514. Epub 2011 Sep 6.

The genetics of hybrid incompatibilities.

Author information

1
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA. barbash@cornell.edu

Abstract

Incompatibilities in interspecific hybrids, such as sterility and lethality, are widely observed causes of reproductive isolation and thus contribute to speciation. Because hybrid incompatibilities are caused by divergence in each of the hybridizing species, they also reveal genomic changes occurring on short evolutionary time scales that have functional consequences. These changes include divergence in protein-coding gene sequence, structure, and location, as well as divergence in noncoding DNAs. The most important unresolved issue is understanding the evolutionary causes of the divergence within species that in turn leads to incompatibility between species. Surprisingly, much of this divergence does not appear to be driven by ecological adaptation but may instead result from responses to purely mutational mechanisms or to internal genetic conflicts.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center