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J Am Chem Soc. 2011 Oct 12;133(40):15834-7. doi: 10.1021/ja205471n. Epub 2011 Sep 16.

Controlled formation of peptide bonds in the gas phase.

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1
Department of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.

Abstract

Photoexcitation (using 157 nm vacuum ultraviolet radiation) of proton-bound peptide complexes leads to water elimination and the formation of longer amino acid chains. Thus, it appears that proton-bound dimers are long-lived intermediates along the pathway to peptide formation. Product specificity can be controlled by selection of specific complexes and the incorporation of blocking groups at the N- or C-termini. The product peptide sequences are confirmed using collision-induced dissociation.

PMID:
21910477
PMCID:
PMC3202421
DOI:
10.1021/ja205471n
[Indexed for MEDLINE]
Free PMC Article
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