Send to

Choose Destination
Mol Neurobiol. 2011 Dec;44(3):313-20. doi: 10.1007/s12035-011-8201-5. Epub 2011 Sep 10.

Seven-pass transmembrane cadherins: roles and emerging mechanisms in axonal and dendritic patterning.

Author information

Research Group Axon Guidance and Neuronal Connectivity, Max Planck Institute of Neurobiology, Am Kolpferspitz 18, 82152 Martinsried, Germany.


The Flamingo/Celsr seven-transmembrane cadherins represent a conserved subgroup of the cadherin superfamily involved in multiple aspects of development. In the developing nervous system, Fmi/Celsr control axonal blueprint and dendritic morphogenesis from invertebrates to mammals. As expected from their molecular structure, seven-transmembrane cadherins can induce cell-cell homophilic interactions but also intracellular signaling. Fmi/Celsr is known to regulate planar cell polarity (PCP) through interactions with PCP proteins. In the nervous system, Fmi/Celsr can function in collaboration with or independently of other PCP genes. Here, we focus on recent studies which show that seven-transmembrane cadherins use distinct molecular mechanisms to achieve diverse functions in the development of the nervous system.

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center