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Mol Neurobiol. 2011 Dec;44(3):313-20. doi: 10.1007/s12035-011-8201-5. Epub 2011 Sep 10.

Seven-pass transmembrane cadherins: roles and emerging mechanisms in axonal and dendritic patterning.

Author information

1
Research Group Axon Guidance and Neuronal Connectivity, Max Planck Institute of Neurobiology, Am Kolpferspitz 18, 82152 Martinsried, Germany.

Abstract

The Flamingo/Celsr seven-transmembrane cadherins represent a conserved subgroup of the cadherin superfamily involved in multiple aspects of development. In the developing nervous system, Fmi/Celsr control axonal blueprint and dendritic morphogenesis from invertebrates to mammals. As expected from their molecular structure, seven-transmembrane cadherins can induce cell-cell homophilic interactions but also intracellular signaling. Fmi/Celsr is known to regulate planar cell polarity (PCP) through interactions with PCP proteins. In the nervous system, Fmi/Celsr can function in collaboration with or independently of other PCP genes. Here, we focus on recent studies which show that seven-transmembrane cadherins use distinct molecular mechanisms to achieve diverse functions in the development of the nervous system.

PMID:
21909747
PMCID:
PMC3229701
DOI:
10.1007/s12035-011-8201-5
[Indexed for MEDLINE]
Free PMC Article

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