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PLoS One. 2011;6(8):e24109. doi: 10.1371/journal.pone.0024109. Epub 2011 Aug 31.

RosettaRemodel: a generalized framework for flexible backbone protein design.

Author information

1
Department of Biochemistry, University of Washington, Seattle, Washington, United States of America.

Abstract

We describe RosettaRemodel, a generalized framework for flexible protein design that provides a versatile and convenient interface to the Rosetta modeling suite. RosettaRemodel employs a unified interface, called a blueprint, which allows detailed control over many aspects of flexible backbone protein design calculations. RosettaRemodel allows the construction and elaboration of customized protocols for a wide range of design problems ranging from loop insertion and deletion, disulfide engineering, domain assembly, loop remodeling, motif grafting, symmetrical units, to de novo structure modeling.

PMID:
21909381
PMCID:
PMC3166072
DOI:
10.1371/journal.pone.0024109
[Indexed for MEDLINE]
Free PMC Article

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