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Curr Opin Virol. 2011 Aug;1(2):101-9. doi: 10.1016/j.coviro.2011.06.005.

Structures of giant icosahedral eukaryotic dsDNA viruses.

Author information

1
Department of Chemistry, University of Texas at El Paso, 79968, USA.

Abstract

In the last twenty years, numerous giant, dsDNA, icosahedral viruses have been discovered and assigned to the nucleocytoplasmic large dsDNA virus (NCLDV) clade. The major capsid proteins of these viruses consist of two consecutive jelly-roll domains, assembled into trimers, with pseudo 6-fold symmetry. The capsomers are assembled into arrays that have either p6 (as in Paramecium bursaria Chlorella virus-1) or p3 symmetry (as in Mimivirus). Most of the NCLDV viruses have a membrane that separates the nucleocapsid from the external capsid.

KEYWORDS:

Assembly; Double-jelly-roll capsid protein; Giant icosahedral DNA viruses; Unique vertices

PMID:
21909343
PMCID:
PMC3167175
DOI:
10.1016/j.coviro.2011.06.005
[Indexed for MEDLINE]
Free PMC Article

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