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Cancer Cell. 2011 Sep 13;20(3):283-4. doi: 10.1016/j.ccr.2011.08.017.

DePICTing p53 activation: a new nucleolar link to cancer.

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1
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel.

Abstract

p53 activation by ribosomal biogenesis stress is important for tumor suppression. In the August issue of Nature Medicine, Sasaki et al. identify PICT1 as a regulator of this process. PICT1 sequesters ribosomal protein RPL11 in the nucleolus, attenuating p53 induction. Excessive PICT1 may dampen the p53 response and promote cancer.

PMID:
21907918
DOI:
10.1016/j.ccr.2011.08.017
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