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Cancer Cell. 2011 Sep 13;20(3):281-2. doi: 10.1016/j.ccr.2011.08.020.

Ras, ROS and proteotoxic stress: a delicate balance.

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Urologic Oncology Branch, National Cancer Institute, Center for Cancer Research, Bethesda, MD 20892, USA.

Abstract

Ras-deregulated cells require reactive oxygen species for proliferation. They survive the resultant proteotoxic stress by maintaining sufficient levels of reduced glutathione and optimally functioning stress response machinery. In this issue of Cancer Cell, De Raedt et al. identify a novel strategy that utilizes this dependency to cause cell death.

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