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Fitoterapia. 2011 Dec;82(8):1241-8. doi: 10.1016/j.fitote.2011.08.019. Epub 2011 Sep 1.

Inhibition of mitochondrial respiratory chain is involved in triptolide-induced liver injury.

Author information

1
Jiangsu Center for Drug Screening, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.

Abstract

Triptolide, a diterpenoid epoxide, is one of the major active ingredients of Tripterygium wilfordii Hook F, a woody vine plant called lei gong teng in China, which is used in traditional Chinese Medicine (TCM) for treating many diseases. In this paper, we investigate the relation between inhibition of mitochondrial respiratory chain and liver injury induced by triptolide. Results indicate that the secondary β-oxidation impairment caused by inhibition of mitochondrial respiratory chain is involved in triptolide-induced liver injury, which featured by microvesicular steatosis, hyperlactacidemia and enhanced oxidant stress, although other mechanisms of triptolide-induced liver injury may also exist.

PMID:
21907767
DOI:
10.1016/j.fitote.2011.08.019
[Indexed for MEDLINE]

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