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Bioorg Med Chem. 2011 Oct 1;19(19):5813-32. doi: 10.1016/j.bmc.2011.08.014. Epub 2011 Aug 22.

Novel thiophenyl C-aryl glucoside SGLT2 inhibitors as potential antidiabetic agents.

Author information

1
Research Center, Green Cross Corporation, 303 Bojeong-Dong, Giheung-Gu, Yongin, Gyeonggi-Do 446-770, Republic of Korea.

Abstract

Novel thiophene C-aryl glucoside SGLT2 inhibitors were designed and synthesized. Two different types of thiophene derivatives were readily prepared. Among the compounds tested, ethylphenyl at the distal ring 71p showed the best in vitro inhibitory activity in this series to date (IC(50)=4.47 nM) against SGLT2.

PMID:
21906953
DOI:
10.1016/j.bmc.2011.08.014
[Indexed for MEDLINE]

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