Format

Send to

Choose Destination
Am J Kidney Dis. 2012 Mar;59(3):356-63. doi: 10.1053/j.ajkd.2011.07.012. Epub 2011 Sep 9.

The risk of infection-related hospitalization with decreased kidney function.

Author information

1
Department of Medicine, University of California Davis, USA. lorien.dalrymple@ucdmc.ucdavis.edu

Abstract

BACKGROUND:

Moderate kidney disease may predispose to infection. We sought to determine whether decreased kidney function, estimated by serum cystatin C level, was associated with the risk of infection-related hospitalization in older individuals.

STUDY DESIGN:

Cohort study.

SETTING & PARTICIPANTS:

5,142 Cardiovascular Health Study (CHS) participants with measured serum creatinine and cystatin C and without estimated glomerular filtration rate (eGFR) <15 mL/min/1.73 m(2) at enrollment.

PREDICTOR:

The primary exposure of interest was eGFR using serum cystatin C level (eGFR(SCysC)).

OUTCOME:

Infection-related hospitalizations during a median follow-up of 11.5 years.

RESULTS:

In adjusted analyses, eGFR(SCysC) categories of 60-89, 45-59, and 15-44 mL/min/1.73 m(2) were associated with 16%, 37%, and 64% greater risk of all-cause infection-related hospitalization, respectively, compared with eGFR(SCysC) ≥90 mL/min/1.73 m(2). When cause-specific infection was examined, eGFR(SCysC) of 15-44 mL/min/1.73 m(2) was associated with an 80% greater risk of pulmonary and 160% greater risk of genitourinary infection compared with eGFR(SCysC) ≥90 mL/min/1.73 m(2).

LIMITATIONS:

No measures of urinary protein, study limited to principal discharge diagnosis.

CONCLUSIONS:

Lower kidney function, estimated using cystatin C level, was associated with a linear and graded risk of infection-related hospitalization. These findings highlight that even moderate degrees of decreased kidney function are associated with clinically significant higher risks of serious infection in older individuals.

PMID:
21906862
PMCID:
PMC3288732
DOI:
10.1053/j.ajkd.2011.07.012
[Indexed for MEDLINE]
Free PMC Article

Publication type, MeSH terms, Grant support

Publication type

MeSH terms

Grant support

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center