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Gen Dent. 2011 Jul-Aug;59(4):302-8.

Oral erythema multiforme major: a triple case report.

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  • 1Department of Oral Diagnostic Services, Howard University College of Dentistry, Washington, DC, USA.


This article presents three cases of erythema multiforme (EM) major with predominant oral mucosal lesions. Two males, aged 28 and 10, and a 19-year-old woman came to the clinic with oral vesiculoerosive lesions consistent with a diagnosis of EM major. All three patients reported histories consistent with an initial oral herpetic infection. Management with topical and systemic steroids resolved the lesions successfully in all three cases. The relatively recent literature has documented differences between EM and Stevens-Johnson syndrome. It is important for dentists to understand the etiology of EM and the associated diagnostic and management issues.

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