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Bioorg Med Chem Lett. 2011 Oct 15;21(20):6054-7. doi: 10.1016/j.bmcl.2011.08.065. Epub 2011 Aug 22.

A compound isolated from Schisandra chinensis induces apoptosis.

Author information

1
Division of Bioscience and Biotechnology, BMIC, Konkuk University, Seoul 143-701, Republic of Korea.

Abstract

Schizandra chinensis has been known to have five predominant tastes: salty, sweet, sour, astringent, and bitter. It has also been shown to have various effects on the cardiovascular system, gastrointestinal system, anti-inflammatory, central nervous system, endocrine system, and stress protect. However, its anti-cancer activity on colon carcinoma HCT-116 cells has not been yet been examined. Thus, in this study, we attempted to isolate a compound from Schisandra chinensis that induced apoptosis in HCT-116 cells. An active compound was found and identified to be Gomisin A. It displayed apoptotic activity through caspase-7 cleavage in colon carcinoma HCT-116 cells. In addition, we further assessed the effects of this compound using long-term survival clonogenic assay with HCT116 cells.

PMID:
21903389
DOI:
10.1016/j.bmcl.2011.08.065
[Indexed for MEDLINE]

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